SkinPro - The Juvenate Difference – Vitamin A Actives - NOV 2023

The Juvenate Difference
– Vitamin A Actives

Granactive Retinoid ( Hydroxypinacolone Retinoate or HPR) is a well researched
and clinically validated modern form of Vitamin A.

Unlike Retinyl Palmitate, Acetate, Retinol and Retinaldehyde, Granactive Retinoid doesn’t need to go through a conversion process in the skin to become the active form of Vitamin A (Retinoic Acid) Normally, each conversion step will naturally produce Free Radicals as a byproduct, so less conversion steps, less irritation.
More direct action = quicker action. For daily application, we can deliver all of the wonderful benefits of Vitamin A without any downside.

Granactive Retinoid can get to work in your skin quickly.

When you use a serum or cream with in it, this active is getting to work in your skin straight away. It’s like eating a delicious salted caramel artisan chocolate, as soon as you pop a square into your mouth – POW – deliciousness.

Remember, this isn’t the same for retinol and your other forms of retinoids. Retinol doesn’t ‘taste’. When you first apply a retinol serum or cream. It needs to be converted before your skin starts using it. Because your skin doesn’t recognise retinol, it’s like eating a chocolate square without taking the cellophane off. Your skin needs to ‘unwrap’ the chocolate before it can enjoy the deliciousness

In the Journal of Cosmetic Dermatology. 2020 Nov, A study was conducted comparing Retinoid stability and degradation kinetics in commercial cosmetic products.

The study tested different retinoids against each other. They found that at a temperature slightly above room temp – maybe what your bathroom gets to after a steamy shower – some retinoids only had 20% left in the bottle after 6 months. That means a full 80% of the retinoid had gone off and Light degradation was more pronounced than temperature-induced degradation.

HPR was found to be very stable in the tested formulation at 25°C after 6 months (95% of the initial content remained). High chemical stability was also evident at 40°C (97% of the initial content remained after 3 months)

HPR had greater levels of gene transcription than Rol [retinol] at the same concentrations, and was less cytotoxic to cells at a 10 times higher concentration.  Procollagen ELISA results showed that skins treated with HPR significantly increased procollagen production compared with untreated control skins, and was similar to ATRA [all-trans retinoic acid]. Qualitative assessment of collagen levels from histologic staining of skins corroborated these results, with the highest dose of HPR out-performing ATRA.

Even on an impaired barrier - There may be some sloughing initially, which might seem like a red flag, it’s not. We know, upon application, the ingredient binds directly to retinoid receptors. This has an immediate effect on DNA, and begins directing the skin’s proteins and enzymes to do certain things—one of which is to help eliminate dysfunctional/Damaged cells.

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